HUMAN HAIRLESS GENE, PROTEIN AND USES THEREOF

摘要

The present invention provides an isolated nucleic acid which encodes a wildtype or mutant human hairless protein. The present invention further provides an isolated wildtype or mutant human hairless protein. In addition, the present invention provides methods of isolating a nucleic acid encoding a wildtype human hairless-related protein in a sample containing nucleic acid, methods for identifying a compound which is capable of enhancing or inhibiting expression of a human hairless protein, methods for identifying a binding coumpound which is capable of forming a complex with a human hairless protein, and methods for identifying an inhibitory compound which is capable of interfering the capacity of a human hairless protein to form a complex with the binding compound. The invention also provides a transgenic animal and pharmaceutical compositions and methods for treating a human hairless condition.