Process for producing substituted amines and a method for purifying synthetic intermediates therefor

摘要

The present invention relates to a process for producing a substituted amine represented by the general formula (IV):R2NHOR3(IV)(wherein R2 represents a hydrogen atom, a hydrocarbon group or a heteroatom-containing hydrocarbon group, and R3 represents a hydrocarbon group or a heteroatom-containing hydrocarbon group), which comprises the steps of: (b) reacting a hydroxamic acid represented by the general formula (II):R1CONHOH(II)(wherein R1 represents a hydrogen atom or a hydrocarbon group) in the presence of a base with a reaction reagent capable of introducing a hydrocarbon or a heteroatom-containing hydrocarbon group to an oxygen atom and/or a nitrogen atom to form a substituted hydroxamic acid represented by the general formula (III): (wherein R1, R2 and R3 possess the same meanings as defined above), (c) hydrolyzing said substituted hydroxamic acid (III) in the presence of a base or an acid to produce a substituted amine represented by the general formula (IV):R2NHOR3(IV)(wherein R2 and R3 possess the same meanings as defined above). The present further relates to a method for purifying a synthetic intermediate for said substituted amine.