| 摘要 |
Disclosed is a method of promoting tissue regeneration at a wound site on an internal organ in a subject. The method comprises applying a porous biodegradable implant to said wound site after injury. The implant has the following characteristics: a) the pores of said implant have an average diameter of between about 1 mu m and about 300 mu m; b) the implant has a minimum water content of at least about 80 %; and a minimum specific surface area of at least about 10<3> mm<2> per cm<3>; c) between about 20 % to about 80 % by weight of the implant is biodegraded at the wound site during the time period required for a wound of about the same severity, size and tissue type to complete about one half of the contraction which normally takes place in the absence of the implant; d) the implant comprises: i) a three-dimensional network of polymers which is substantially insoluble under physiological conditions; and ii) one or more specific cell-binding fragments. Also disclosed is a porous biodegradable implant having the characteristics described above, wherein the implant is a microparticle having an average diameter from about 10 mu m to about 1000 mu m. Also disclosed is a method of promoting tissue regeneration at an internal wound site in a subject. The method comprises applying the porous biodegradable microparticles to the wound site after injury. |
