发明名称 PROCESS FOR MAKING CERTAIN BENZOIC ACID COMPOUNDS
摘要 <p>The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then treating with an electrophilic reagent which provides Q1, or a functional moiety which is then transformed to Q1, producing 1-bromo-2,4-difluoro-3-Q1-benzene; (b) treating the 1-bromo-2,4-difluoro-3-Q1-benzene with an alkali or alkaline earth metal or organometallic reagent; then treating with carbon dioxide, or with a formylating agent followed by oxidation, to produce 2,4-difluoro-3-Q1-benzoic acid. The subject invention also involves optional additional steps to further modify Q1, or to substitute a non-hydrogen moiety at the 5-position, at the 6-position, or at both, of the phenyl ring of the 2,4-difluoro-3-Q1-benzoic acid.</p>
申请公布号 WO9935117(A1) 申请公布日期 1999.07.15
申请号 WO1998IB02116 申请日期 1998.12.28
申请人 THE PROCTER & GAMBLE COMPANY 发明人 LEDOUSSAL, BENOIT;ZHENG, XIAOMIN, SHARON;ALMSTEAD, JI-IN, KIM;GRAY, JEFFREY, LYLE
分类号 C07C51/15;C07C51/347;C07C51/363;C07C51/367;C07C63/70;C07C65/21;C07C69/76;C07C201/08;C07C205/58;(IPC1-7):C07C51/15;C07C63/04;C07C65/28 主分类号 C07C51/15
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