发明名称 |
RNA polymerase II holoenzyme from Saccharomyces cerevisiae |
摘要 |
An RNA polymerase II holoenzyme that contains, in addition to RNA polymerase, a subset of the general transcription factors together with nine SRB proteins is described. This holoenzyme will selectively initiate transcription in vitro when supplemented with TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
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申请公布号 |
US5922585(A) |
申请公布日期 |
1999.07.13 |
申请号 |
US19940218265 |
申请日期 |
1994.03.25 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
YOUNG, RICHARD A.;KOLESKE, ANTHONY J.;THOMPSON, CRAIG M. |
分类号 |
C07K14/395;C07K14/47;C07K16/14;C12N9/12;C12N15/54;G01N33/573;(IPC1-7):C12N9/12;C12N15/31 |
主分类号 |
C07K14/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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