发明名称 INTEGRIN RECEPTOR ANTAGONISTS
摘要 The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the vitronectin receptors .alpha.v.beta.3 and/or .alpha.v.beta.5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.
申请公布号 CA2315370(A1) 申请公布日期 1999.06.24
申请号 CA19982315370 申请日期 1998.12.14
申请人 MERCK & CO., INC. 发明人 DUGGAN, MARK E.;PERKINS, JAMES J.;MEISSNER, ROBERT S.
分类号 C07D401/06;A61K31/40;A61K31/4015;A61K31/4375;A61K31/66;A61K45/06;A61P9/00;A61P9/10;A61P19/08;A61P19/10;A61P27/02;A61P29/00;A61P31/12;A61P35/00;A61P43/00;C07D207/26;C07D401/14;C07D413/06;C07D471/04;C07D519/00;(IPC1-7):A61K31/435 主分类号 C07D401/06
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