| 摘要 |
<p>Excellent sweetener compositions containing aspartame (APM) and APM derivative and being similar to sucrose in tasting properties, which can be easily, uniformly and efficiently produced at a high purity by the process for producing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester by the reductive alkylation of APM and 3,3-dimethylbutyraldehyde, which comprises using 3,3-dimethylbutyraldehyde in an amount at most equimolar to APM for producing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester from a portion of the APM existing in the reaction system, then separating the reducing agent from the liquid reaction mixture, and effecting crystallization followed by the separation of the crystals thus precipitated.</p> |
