发明名称 INTEGRIN RECEPTOR ANTAGONISTS
摘要 The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha..beta.3, .alpha..beta.5, and/or .alpha..beta.6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
申请公布号 CA2315232(A1) 申请公布日期 1999.06.24
申请号 CA19982315232 申请日期 1998.12.14
申请人 MERCK & CO., INC. 发明人 DUGGAN, MARK E.;PERKINS, JAMES J.;MEISSNER, ROBERT S.
分类号 C07D487/04;A61K31/422;A61K31/4375;A61K31/445;A61K31/4525;A61K31/4545;A61K31/495;A61K31/506;A61K41/00;A61K45/06;A61P9/00;A61P17/02;A61P19/08;A61P19/10;A61P27/02;A61P29/00;A61P31/12;A61P35/00;A61P43/00;C07D401/06;C07D401/14;C07D417/14;C07D471/04;C07D471/08;(IPC1-7):A61K31/495 主分类号 C07D487/04
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