摘要 |
<p>The present invention relates generally to a broad-spectrum phospholipase enzyme inhibitor and uses therefor. More particularly, the present invention provides an inhibitor of phospholipase A2 enzymes, wherein the inhibitor is a proteinaceous molecule including a peptide, polypeptide or protein which is derivable from the serum of a venomous animal. The present invention extends to derivatives, homologues, analogues, mimetics and functional chemical equivalents of the phospholipase A2 inhibitor. The phospholipase A2 inhibitor of the present invention is particularly useful in the production of a wide range of human and veterinary pharmaceutical products such as for the treatment of conditions involving phospholipase A2 including, but not limited to, rheumatoid arthritis, osteoarthritis, asthma, allergic conditions, psoriasis, autoimmune disorders, inflammatory disease, multiple organ failure, acute pancreatitis, acute lung failure, septic shock, adult respiratory distress syndrome, insect and snake bite, amongst others.</p> |