摘要 |
FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to new compounds of secomacrolides and secoazalides class - potential intermediate compounds used for synthesis of new macrolide and azalide antibiotics and to a method of their synthesis and intermediate compounds for their synthesis. Invention describes 9a-azalide fragments of macrolide antibiotics of an azalide class of the general formula (I) <EMI ID=0.294 HE=66 WI=54 TI=CHI> where R<SB>1</SB> and R<SB>2</SB> are similar and mean H or CH<SB>3</SB>; R<SB>3</SB> and R<SB>4</SB> are distinct and mean H or CH<SB>3</SB>; Y means O when Z means CH<SB>3</SB> and Y means NH when Z means CH(CH<SB>3</SB>)CH(OH)COH(CH<SB>3</SB>)CH(OH)C<SB>2</SB>H<SB>5</SB> or their pharmaceutically acceptable salts of inorganic or organic acids. EFFECT: new compounds indicated above, improved method of synthesis. 39 cl, 22 ex
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