PRESENILIN-1 GENE PROMOTER

摘要

An isolated DNA molecule that directs neuron-specific transcription of a downstream heterologous DNA segment (a promoter segment) in a mammalian cell is disclosed. The isolated DNA molecule contains a promoter segment from the mouse genomic Presenilin-1 DNA, or a DNA sequence that hybridize to such DNA and directs neuron-specific transcription of a downstream heterologous DNA segment in a mammalian cell. DNA constructs comprising such promoter segments and various uses thereof are also disclosed.