PRODUCTION OF BETA-HYDROXYSULFOXIDE

摘要

PROBLEM TO BE SOLVED: To provide a simple process for the production of a β-hydroxysulfoxide useful as a synthetic intermediate for pharmaceuticals and amino acids. SOLUTION: The objective β-hydroxysulfoxide derivative expressed by the general formula R<1> (S=O)CH2 -CH(OSiR<2> R<3> R<4> )-R (R<1> , R<2> , R<3> and R<4> are each independently an alkyl or an aromatic group; R is a (substituted)aromatic group or vinyl group) and/or β-hydroxysulfoxide expressed by the general formula R<1> (S=O)CH2 -CH(OH)-R can be produced by reacting an aldehyde expressed by the general formula RHC=O with a sulfinylmethylsilane expressed by the general formula R<1> (S=O)CH2 -SiR<2> R<3> R<4> in the presence of fluorine ion.