发明名称 |
Preparation of aminomethyl-phenylimidazoles |
摘要 |
Aminomethyl-phenylimidazoles are produced by reaction of an ester of a hydroxymethyl-phenylimidazole with an amine. A particularly preferred ester is the acetate ester. The aminomethyl-phenylimidazoles have useful properties as highly selective partial agonists or antagonists at brain dopamine receptor subtypes. A preferred compound prepared is 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine. Esters of the hydroxymethyl-phenylimidazoles are useful intermediates.
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申请公布号 |
US5905152(A) |
申请公布日期 |
1999.05.18 |
申请号 |
US19970907118 |
申请日期 |
1997.08.06 |
申请人 |
SCHERING CORPORATION |
发明人 |
GALA, DINESH;MERGELSBERG, INGRID;STEINMAN, MARTIN;GIESINGER, BRIGITTE;SCHERER, DOMINIK |
分类号 |
C07D403/12;(IPC1-7):C07D403/12;C07D403/14;C07D403/04;C07D403/00 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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