发明名称 |
Chimeric vaccine against tick-borne encephalitis virus |
摘要 |
A live, attenuated chimeric virus vaccine against tick-borne encephalitis virus comprising the preM and E structural genes of the tick-borne encephalitis Langat virus and the non-structural genes of the mosquito-borne dengue virus. The live chimeric vaccine was administered intraperitoneally and exhibited complete attenuation in mice while at the same time providing protection against subsequent challenge with the virulent parental Langat virus. |
申请公布号 |
AU9794198(A) |
申请公布日期 |
1999.04.27 |
申请号 |
AU19980097941 |
申请日期 |
1998.10.08 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED |
发明人 |
ALEXANDER PLETNEV;RUHE MEN;ROBERT CHANOCK;CHING-JUH LAI |
分类号 |
A61K38/00;A61K39/00;A61K39/295;C07K14/18;C12N7/04;C12N15/40 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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