TAXANE COMPOSITION AND METHOD

摘要

The invention provides a taxane storage solution having improved solubility and toxicity properties. The solution comprises a taxane, such as taxol or docataxel, in a pharmaceutically pure form, a polyoxyethylene sorbitan fatty acid monoester, polyethoxylated castor oil, and ethanol. The polysorbitan and polyethoxylated castor oil are present in amounts effective to reduce the toxicity of the taxane relative to the toxicity observed when either the polysorbitan or polyethoxylated castor oil is used in the absence of the other. Also disclosed is a therapeutic method which employs the solution, and a vehicle which may be used in the method.