| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject composition capable of lowering abnormally high CRP value and useful for treating cytokine-related diseases such as rheumatism, inflammation, allergy, atherosclerosis and hepatitis, by including a specific benzimidazole and others. SOLUTION: This pharmaceutical composition contains a benzimidazole of the formula (R is a 1-5C alkyl, hydroxyphenyl or methoxyphenyl) such as 2-(4-methoxyphenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl)-be nzimidazole, a 3H tautomer thereof, an optically active antipode thereof or a pharmaceutically acceptable acid addition salt thereof. It is preferable that the daily dose of this compound of the formula is 1.0-2.5 mg per adult. |
