PROCESS FOR PRODUCING CYTIDINE DIPHOSPHATE CHOLINE

摘要

A process for producing cytidine diphosphate choline is described. The process comprises carrying out an enzymatic reaction using microorganisms having the enzyme activities of cytidine-5'-triphosphate synthetase (pyrG), cholinephosphate cytidylyltransferase (CCT) and choline kinase (CKI) and a microorganism capable of producing uridine-5'-triphosphate from orotic acid as the enzyme sources, and orotic acid and choline and/or phosphorylcholine as the substrates; allowing cytidine diphosphate choline to accumulate in the reaction mixture; and recovering cytidine diphosphate choline from said reaction mixture.