ARYL GLYCINAMIDE DERIVATIVES, METHODS OF PRODUCING THESE SUBSTANCES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS

摘要

The invention concerns novel aryl glycinamide derivatives ofgeneral formulaand pharmaceutically acceptable salts thereof, the symbols havingthe following meanings: R1 and R2 together with the nitrogen atomto which they are bound form a ring of formulashown in which p is 2 or 3 and X stands for oxygen. N(CH2)nR6 orCR7R8; and R3, R4, R5, R6, R7, R8, Ar and n have the meaningsindicated in the description. The invention also concerns theproduction and use of these substances. The novel compounds arevaluable neurokinin (tachykinin) antagonists.(31) 9100050 (32) 11.01.919100050 (32) 11.01.91