| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound useful as a raw material for an important intermediate for the syntheses of quinolone carboxylic acids useful as medicines, especially antibacterial agents and antiviral agents. SOLUTION: A compound of the formula (R is H, a 1-10C alkyl, a 3-10C cycloalkyl or the like), e.g. 2,3,4-trifluoro-5-iodobenzoic acid. The compound of the formula is obtained by reacting 1 mole of 5-amino-2,3,5-trifluorobenzoic acid with 2.5-10 moles of hydroiodic acid in the presence of 0.4-1.2 moles of a cuprous halide of the formula: CuX (X is a halogen) (preferably cuprous iodide) and 1.5-3 moles of an alkali metal nitrite (e.g. sodium nitrite) in 0.1-3 liter of a solvent (e.g. water, methanol, acetone, acetonitrile) preferably at 0-30 deg.C for 0. 5-3 hr. |
