摘要 |
FIELD: medicine. SUBSTANCE: invention describes new process for preparing 6alpha,9alpha-difluorinated steroids of formula I: 6alpha,9alpha wherein R is hydrogen atom or ester residue. The process comprises treating compound of formula II: <EMI ID=0.645 HE=42 WI=48 TI=CHI> with oxidative destructing agent to give compound of formula III: <EMI ID=0.646 HE=36 WI=51 TI=CHI> wherein functional ketone group in position 3 is protected in the form of enol ether or ester, and functional acid group is optionally protected in position <EMI ID=0.647 HE=36 WI=51 TI=CHI> in the form of ester to give compound of formula IV: 17beta, wherein R is as defined above, and <EMI ID=0.648 HE=36 WI=54 TI=CHI> is ether or ester enol residue which is treated with electrophilic fluorinating agent to give compound of formula V: R<SB>1</SB>, compound is treated with nucleophilic fluorinating agent to give compound of formula I which is, when R is ester residue, optionally saponified to give corresponding acid. The process is advantageous in that only functional ketone group is protected in position 3 in the form of enol ether or ester to give compound of formula IV. The invention also describes new compounds of formula VI: <EMI ID=0.649 HE=42 WI=48 TI=CHI> wherein R is as defined in formula I, X is hydrogen or fluorine atom, and Y bonded with dotted lines is essentially system of 3-keto <EMI ID=0.650 HE=42 WI=48 TI=CHI>, or X is hydrogen atom, and Y bonded with dotted lines is essentially system of Δ4 in which 3-OR<SB>1</SB> Δ3,5 is as defined in formula I. Compounds are useful as intermediate compounds for preparing steroidal drugs. EFFECT: more efficient preparation process. 10 cl, 4 ex
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