BIFUNCTIONAL RESIN COMPOSITION FOR THE SIMULTANEOUS SEPARATION OF CARBOHYDRATES AND ORGANIC ACIDS IN LIQUID CHROMATOGRAPHY

摘要

An improved bifunctional chromatography resin composition which allows for the separation of both carbohydrates and organic acids during a single liquid chromatography run. The resin compositions comprise synthetic resin support particles to which are attached (1) ligand exchange functional groups which comprise a metal cation useful for the separation of carbohydrates in mixtures thereof, and (2) anion exchange functional groups which are capable of separating organic acids from mixtures thereof. The ligand exchange and anion exchange functional groups function independently in the resin composition, thereby allowing the separation of both carbohydrates and organic acids in a single liquid chromatography run.