| 摘要 |
Compound, compositions containing compounds, methods of using compounds, and processes of making compounds, of formula (I) containing at least one ring nitrogen, or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer or mixtures thereof, wherein: X is double-bonded oxygen, or -OH; when R7 is present, it is hydrogen or lower alkyl; y represents the atoms necessary to form a fused mono, bi- or tricyclic, carbocylic or heterocyclic ring, wherein each individual ring has 5-6 ring member atoms; and Z is (i) -CH2CHR3- wherein R2 and R3 are independently hydrogen, alkyl, aryl or aralkyl; (ii) -R6C=CR3- wherein R3 and R6 are independently hydrogen, lower alkyl, aryl, aralkyl, halo, -NO2, -COOR7, or -NR7R8 where R8 is independently hydrogen or C1-C9 alkyl, or R6 and R3, taken together, form a fused aromatic ring, wherein each individual ring has 56 ring members; (iii) -R2C=N-; (iv) -CR2(OH)-NR7; or (v) -C(O)-NR7-.
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