OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS

摘要

The invention relates to compounds of formula (I) [wherein: ring Z is, for example, a 6-membered aromatic heterocyclic ring containing 1 or 2 nitrogen atoms; R<1> represents hydrogen, C1-4alkyl, C1-4alkoxymethyl, di(C1-4alkoxy)methyl or C1-4alkanoyl; R<2> represents, for example, halogeno, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, C1-3alkylsulphonyl, carbamoyl, N-C1-3alkylcarbamoyl, N,N-di(C1-3alkyl)carbamoyl, aminosulphonyl, N-C1-3alkylaminosulphonyl or N,N-di(C1-3alkyl)aminosulphonyl; n is an integer from 0 to 3; m is an integer from 0 to 4; and R<3> represents, for example, hydroxy, halogeno, nitro, trifluoromethyl, C1-3alkyl, cyano, amino or R<15>X<7> (wherein R<15> is, for example, an optionally substituted 5-6-membered carbocyclic or heterocyclic group or a group which is alkenyl, alkynyl or optionally substituted alkyl, which alkyl group may contain a heteroatom linking group, which alkenyl, alkynyl or alkyl group may carry a terminal optionally substituted group selected from alkyl and a 5-6-membered carbocyclic or heterocyclic group and X<7> is a linker group such as -O- or -NR-)] and salts thereof, processes for their preparation and pharmaceutical compositions containing them as active ingredient. The compounds of formula (I) and salts thereof inhibit the effects of VEGF and FGF, properties of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.