发明名称 DNA encoding biosynthetic binding protein for cancer marker
摘要 Disclosed is DNA encoding a single-chain Fv (sFv) polypeptide defining a binding site which exhibits the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen, the sFv includes at least two polypeptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N-terminus of the other, the amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), the CDRs conferring immunological binding to the c-erbB-2 or c-erbB-2-related tumor antigen.
申请公布号 US5877305(A) 申请公布日期 1999.03.02
申请号 US19940356786 申请日期 1994.12.12
申请人 CHIRON CORPORATION;CREATIVE BIOMOELCULES, INC. 发明人 HUSTON, JAMES S.;HOUSTON, L. L.;RING, DAVID B.;OPPERMANN, HERMANN
分类号 C12N15/09;A61K39/395;A61K49/00;A61K51/00;A61K51/08;A61P35/00;C07H21/04;C07K16/22;C07K16/28;C07K16/30;C07K16/32;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/62;C12N15/66;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):A61K39/395 主分类号 C12N15/09
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