HIV MATRIX PROTEIN TYROSINE POSITION 29 POCKET BINDERS

摘要

There is disclosed a structural genus of compounds, defined according to coordinates in three-dimensional space, that binds amino moieties on neighboring lysine residues in a tyrosine residue 29 pocket of the matrix protein component of the HIV preintegration complex (PIC). The compounds and pharmaceutical compositions prevent the PIC from binding to karyopherin alpha and prevent nuclear importation and integration of the HIV viral genome into the host cell DNA. Thus, the inventive compounds and pharmaceutical compositions prevent HIV viral infection.