Certain 3-ketosteroids used to inhibit steroid 5 alpha -reductase

摘要

The invention discloses 3-ketosteroids of the following formula used to inhibit steroid 5 alpha -reductase: <IMAGE> wherein R is OH, C1-C6 alkanoyl, C1-C6 alkanoyloxy, C1-C4 alkanol, COCH2OH, CO2H, CONR7R8, cyclopropoxy, acetylthioalkane, cyclopylamino, 2-2-dimethyldioxolan-4-yl, 1,2-dihydroxyethyl and C1-4 alkanethiol; R1 is hydrogen, hydroxy or C1-6 alkyl; R1 and R2 together may indicate =O, that is an oxygen double bonded to the 17 carbon; R2, R3 and R4 are each independently hydrogen or C1-6 alkyl; R5 and R6 are each independently hydrogen or OH; R5 and R6 together may indicate =O, that is an oxygen double bonded to the 11 carbon; R7 is hydrogen or C1-8 alkyl; R8 is C1-8 alkyl; and with the proviso that, when R is OH, then R1 is hydrogen; and with the proviso that, when R5 is OH, then R6 is hydrogen.