| 发明名称 |
ENDOTHELIN RECEPTOR ANTAGONISTS |
| 摘要 |
The invention relates to novel compounds of formula (I), wherein R represents group (1), X stands for O or S, and R1, R2, R3, R4, R5 and R6 have the meaning cited in Claim 1, or a tauomeric cyclized form. The invention further relates to (E) isomers and their salts. Said novel derivatives exhibit endothelinreceptor antagonistic properties.
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| 申请公布号 |
CA2297315(A1) |
申请公布日期 |
1999.02.04 |
| 申请号 |
CA19982297315 |
申请日期 |
1998.06.29 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG |
发明人 |
CHRISTADLER, MARIA;WILM, CLAUDIA;SCHMITGES, CLAUS JOCHEN;DORSCH, DIETER;OSSWALD, MATHIAS;MEDERSKI, WERNER |
| 分类号 |
A61K31/4245;A61K31/433;A61P9/04;A61P9/10;A61P9/12;A61P11/06;A61P13/08;A61P13/12;A61P29/00;A61P43/00;C07D271/12;C07D285/14;C07D413/04;C07D417/04;(IPC1-7):C07D285/14;A61K31/41 |
主分类号 |
A61K31/4245 |
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