COMPOUNDS OF CYCLIC URETHAN OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF HUMAN AND OTHER MAMMALIAN TREATMENT SUFFERING WITH CARDIAC ARRHYTHMIA AND/OR ATRIAL FIBRILLATION, A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF PATIENTS WITH ARRHYTHMIA AND FIBRILLATION

摘要

FIELD: organic chemistry. SUBSTANCE: invention describes new cyclic urethans of the general formula (I) where X - phenyl; R - covalent bond; Y - furylidene; R1,R2 and R3 - hydrogen or chlorine atom; L - lower alkylamino bound at nitrogen atom to cyclic urethan nitrogen atom; R4 - lower alkylene; A - unsaturated 6-membered heterocycle containing 1 or 2 nitrogen atoms that can be substituted with a lower alkyl or hydroxy(lower)alkyl being one of heterocycle A nitrogen atoms is bound with radical R4; R5 - methylene, or their pharmaceutically acceptable salts. Cyclic urethans show activity against cardiac arrhythmia and atrial fibrillation. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 11 cl, 2 dwg, 1 tbl, 18 ex