| 摘要 |
<p>The present invention discloses an enzyme obtainable from P. chrysogenum which is an O-acetyl-L-serine sulfhydrylase (OAS sulfhydrylase). It is shown for the first time that P. chrysogenum contains an enzyme activity associated with the direct sulfhydrylation pathway. The OAS sulfhydrylase of the invention is able to convert O-acetyl-L-serine (OAS) and sulphide into cysteine and acetate. The present invention thereby provides the possibility to increase the synthesis of L-cysteine via the direct sulfhydrylation pathway by e.g. genetic engineering of a β-lactam production organism, and, consequently, to improve the yield of β-lactams on glucose.</p> |
