| 摘要 |
PURPOSE:To obtain the subject compound useful as a synthetic intermediate for pharmaceuticals from an inexpensive raw material under mild condition in high yield by treating an epihalohydrin with a dehalogenation enzyme originated from microorganism in the presence of an alkali metal cyanide. CONSTITUTION:The objective compound is produced by treating an epihalohydrin with a dehalogenation enzyme originated from microorganism in the presence of an alkali metal cyanide preferably at 5-50 deg.C and pH4-10. The dehalogenation enzyme is e.g. an enzyme produced by Corynebacterium sp. N-2354 (FERM P-10673) which is a new microorganism. |
