发明名称 |
DOWN-REGULATION RESISTANT C3 CONVERTASE |
摘要 |
<p>Native complement pathway proteins modified such that the protein is capable of forming a down-regulation resistant C3 convertase. Preferably the modified protein is a modified human C3 protein. DNA sequences encoding such proteins are also provided, together with DNA constructs. Conjugates comprising such proteins and a specific binding moiety, for example an antibody, are also described, as are uses of such proteins and/or conjugates in therapy.</p> |
申请公布号 |
EP0885301(A1) |
申请公布日期 |
1998.12.23 |
申请号 |
EP19970905334 |
申请日期 |
1997.03.04 |
申请人 |
IMUTRAN LIMITED |
发明人 |
FARRIES, TIMOTHY CHARLES;HARRISON, RICHARD ALEXANDER |
分类号 |
C12N15/09;A61K38/00;A61P43/00;C07K14/47;C07K16/40;C12N9/64;C12N15/12;C12R1/91;(IPC1-7):C12N15/12;C12N15/57;A61K38/17;A61K38/48 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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