CLOSTRIDIUM PERFRINGENS VACCINE

摘要

The present invention relates to detoxified immunogenic derivatives of Clostridi um perfringens -toxin or an immunogenic fragment thereof that have as a characteristic that the y carry a mutation in the .beta.-toxin amino acid sequence, not found in the wild-type . beta.-toxin amino acid sequence. The invention also relates to genes encoding such .beta.-toxins, as we ll as to expression systems expressing such .beta.-toxins. Moreover, the invention relates to bacter ial expression systems expressing a native .beta.-toxin. Finally, the invention relates to vacc ines based upon detoxified immunogenic derivatives of Clostridium perfringens .beta.-toxin, and methods for the preparation of such vaccines.