发明名称 |
ANTIMICROBIAL PEPTIDES DERIVED FROM UBIQUICIDINE |
摘要 |
The invention relates to the use of ubiquicidine or optionally modified peptide fragments derived therefrom for the preparation of a drug for the treatment, diagnostics or prophylaxis of infections in humans and animals. A peptide fragment derived from ubiquicidine comprises for instance a preferably continuous series of at least 3, preferably at least 7-13 amino acids from the amino acid sequence of ubiquicidine: KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS. Hybrid molecules comprise for instance a cationic peptide with an antimicrobial action and/or a peptide fragment of ubiquicidine and/or a derivative thereof and one or more effector molecules.
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申请公布号 |
CA2291894(A1) |
申请公布日期 |
1998.12.03 |
申请号 |
CA19982291894 |
申请日期 |
1998.05.29 |
申请人 |
RIJKSUNIVERSITEIT LEIDEN |
发明人 |
NIBBERING, PETRUS HENDRICUS;VAN DEN BARSELAAR, MARIA THEODORA;HIEMSTRA, PIETER SICCO;PAUWELS, ERNEST KAREL JACOB;FEITSMA, ROLF IDE JOHANNES |
分类号 |
A61K38/00;C07K14/00;C07K14/47;(IPC1-7):C07K7/08;A61K38/04;C07K5/04;C07K7/04;A61K51/08;A61K38/10;C12N15/11;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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