| 摘要 |
PROBLEM TO BE SOLVED: To produce a new epoxy-azetidinone compound useful as an intermediate, etc., for synthesizing 1-oxapenem being an effective inhibitor ofβ-lactamase by epoxydizing an azetidinone compound. SOLUTION: This new epoxy-azetidinone compound is represented by formula I (R<1> is 3-o-chlorophenyl-5-methyl-isoxazol-4-yl-carbonylamino, phthalimide, phenylacetylamino, etc.; R<2> is a 1-4C alkylaminosulfonyl, benzylaminosulfonylh a 1,4-C alkyloxysulfonyl, arylaminosulfonyl, etc.; R<3> is a benzyloxy, a 1-4C alkyloxy, silyloxy, etc.; R<4> and R<5> are each H, a halogen, a 1-4C alkyloxy, etc.) and useful as an intermediate for synthesizingβ-lactamase inhibitor. The compound is produced by subjecting azetidinone compound of formula II to an epoxydizing reaction by using 30% hydrogen peroxide, etc.
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