发明名称 |
COMBINED ELECTROPHORESIS-ELECTROSPRAY INTERFACE AND METHOD |
摘要 |
A system and method for analyzing molecular constituents of a composition sample includes: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5-100 KVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g., +/- 2-8 KVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit, or by conduction through a sheath electrode discharged in an annular sheath flow about the capillary exit.
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申请公布号 |
CA1340133(C) |
申请公布日期 |
1998.11.17 |
申请号 |
CA19880563449 |
申请日期 |
1988.04.06 |
申请人 |
BATTELLE MEMORIAL INSTITUTE |
发明人 |
SMITH, RICHARD D.;UDSETH, HAROLD R.;OLIVARES, JOSE A. |
分类号 |
G01N27/62;B01D57/02;G01N27/26;G01N27/447;G01N27/64;H01J49/04;H01J49/16;(IPC1-7):G01N27/447 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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