| 摘要 |
A soluble polypeptide which has a binding functionality of soluble complement receptor 1 (sCR1) towards C4b and C3b, e.g. a 95kDa sub-sequence of CR1, can be used in the inhibition of a T-cell-mediated or a B-cell-mediated immune response. The invention further concerns production of CR1-related polypeptides in-vivo, ex-vivo and in-vitro; their compositions and uses e.g. nucleic acid sequences encoding said polypeptides as DNA or RNA, recombinant nucleic acid vectors containing such sequences, and cells expressing said polypeptides. |
