发明名称 |
Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties |
摘要 |
Addition of a non-ionic surface active agent to an immune globulin formulation extends the serum half-life of relatively pure and non-aggregated immune globulin suitable for intravenous injectionor infusion. The non-ionic surface active agent may be a sorbitan ester or a polyoxyethylene sorbitan ester of a fatty acid. Formulations of the present invention is therapeutically advantageous over conventional formulations in that an extended serum half-life of the immune globulin improves its therapeutic effectiveness, reduces the frequency of drug administration and/or lowers the therapeutic effective dosage required and cost of treatment. |
申请公布号 |
AU6914998(A) |
申请公布日期 |
1998.10.30 |
申请号 |
AU19980069149 |
申请日期 |
1998.04.07 |
申请人 |
CANGENE CORPORATION |
发明人 |
HUGH W. PRICE;B. MICHAEL R. WOLOSKI |
分类号 |
A61K38/00;A61K39/395;C07K16/34 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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