| 摘要 |
A method of producing a non-human mammalian model of chronic cerebral inflammation is disclosed. The method comprises introducing into the mammal's brain a polynucleotide that does not encode amyloid precursor protein (APP). Applicants have discovered that APP expression is not necessary to mimic the symptoms of human neurodegenerative diseases. The mammalian models mimic in an in vivo system some of the physical manifestations of diseases of the central nervous system, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and encephalopathies. The models are useful in screening putative prophylactic and therapeutic compositions for addressing symptoms of chronic cerebral inflammation. |
