发明名称 |
Process for the preparation of n-(3-hydroxy-succinyl)-amino acid derivatives |
摘要 |
<p>Processes for preparing compounds of the formula (I) are described: P1OOC-CH(OH)-CHR1-CONH-Z wherein P1 is hydrogen or a protecting group, Z is a group -CHR2COOP2 or -CHR2CONR3R4 wherein P2 is hydrogen or a protecting group and R1-R4 are values known in the TNF-inhibitor art. The compounds of the formula (I) are useful in inhibiting TNF and one or more matrix metalloproteinase enzymes. One intermediate in a process of the invention is formula (II).</p> |
申请公布号 |
AU6843498(A) |
申请公布日期 |
1998.10.22 |
申请号 |
AU19980068434 |
申请日期 |
1998.03.25 |
申请人 |
ZENECA LIMITED;ZENECA PHARMA S.A. |
发明人 |
THOMAS GEOFFREY COLERICK BIRD;MARIE-JEANNE PASQUET;JACQUES PELLETER |
分类号 |
C07C55/32;C07C69/63;C07C231/02;C07C231/14;C07C235/12;C07C235/22;C07C237/22;C07C259/06;C07C309/63;C07D305/12 |
主分类号 |
C07C55/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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