METHOD OF PREPARING ISEPAMYCIN, AND INTERMEDIATE COMPOUNDS

摘要

FIELD: medicine, more particularly manufacture of well known aminoglycoside antibiotic. SUBSTANCE: present invention describes the claimed method which comprises reacting hentamycin B in the form of complex with divalent salt with 2- formylmercaptobenzothiazolol, acylating the compound thus formed with N-protected (S) isoserine, subsequently removing protecting groups by basic hydrolysis and recovering the desired product. The claimed method makes it possible to increase yield of the desired product by 25-30%. The present invention also describes initial compound, i.e. N,O-diformyl-(S)-isoserine, N-formyl-(S)- isoserine and 2-formylmercaptobenzothiazole and intermediate triformylisepamycin of formula: and 3,6- di-N-formylhentamytin B of formula: . EFFECT: more efficient preparation method. 11 cl, 7 ex