Antigenic fusionprotein carrying galalpha1,3gal epitopes

摘要

A method for removing an antibody from blood or plasma, said method comprising contacting said blood or plasma with a fusion polypeptide, said fusion polypeptide comprising a first polypeptide operably linked to a second polypeptide, which first polypeptide comprises a part of a P-selectin glycoprotein ligand-1 that mediates binding to selectin and is glycosylated by an ± 1,3 galactosyltransferase, and which second polypeptide comprises an immunoglobulin polypeptide; and thereafter removing the complex from said blood or plasma, thereby removing the antibody from said blood or plasma.