发明名称 |
TRANSCRIPTION FACTOR ISLET-BRAIN 1 (IB1) |
摘要 |
The identification and characterisation of human and rat Islet-Brain 1 (IB1) is disclosed, a transcriptional activator that is involved in the control of the GLUT2 and insulin genes by interacting with homologous cis-regulatory elements of the GLUT2 and insulin promoters. The rat IB1 cDNA encodes a 714 amino acid protein and the human IB1 cDNA a 711 amino acid protein. The use of IB1 polypeptides, nucleic acid, agonists and antagonists in the treatment or diagnosis of diabetes, neurological diseases such as dementia and/or parkinsonism, the inhibition/promotion of apoptosis and cancer is disclosed.
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申请公布号 |
WO9844106(A1) |
申请公布日期 |
1998.10.08 |
申请号 |
WO1998GB00972 |
申请日期 |
1998.04.02 |
申请人 |
NICOD, PASCAL;KIDDLE, SIMON, JOHN;WAEBER, GERARD;BONNY, CHRISTOPHE |
发明人 |
WAEBER, GERARD;BONNY, CHRISTOPHE |
分类号 |
A61K38/00;A61K48/00;C07K14/47;C12N15/12;(IPC1-7):C12N15/12;A61K38/17;C12Q1/68;G01N33/68;C07K17/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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