| 发明名称 |
BRANCHED HYDRAZONE LINKERS. |
| 摘要 |
Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.
|
| 申请公布号 |
MX9804386(A) |
申请公布日期 |
1998.09.30 |
| 申请号 |
MX19980004386 |
申请日期 |
1998.06.02 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DALTON KING;RAYMOND A. FIRESTONE;PAMELA TRAIL |
| 分类号 |
A61K31/00;A61K31/40;A61K31/401;A61K31/4015;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K39/395;A61K47/48;A61P31/00;A61P31/12;A61P35/00;A61P37/00;C07C281/02;C07D207/44;C07D207/452;C07H15/252;(IPC1-7):A61K47/48 |
主分类号 |
A61K31/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
