COMPOSITION FOR PREVENTING DISEASE ACCOMPANYING OXIDATIVE DAMAGE

摘要

PROBLEM TO BE SOLVED: To obtain a composition for treatment and prevention of ischemic damage, oxidative damage and functional deficiency which relates to aging by includingα-phenyl-t-butylnitron PBN) or its spin trapping derivative as an active ingredient into a carrier. SOLUTION: This composition containsα-phenyl-tert-butylnitron(PBN) represented by formula I [X is phenyl or formula II (R is H, ZCO, etc.; Z is a 1-5C alkyl); Y is t-butyl, etc.] or formula III (A and B are each CH3 , etc.) or formula IV (S is H, etc.) or its derivative as an active ingredient and 5,5- dimethylpyrroline-N-oxide orα-(4-pyridyl-1-oxide)-N-t-butylnitron is exemplified as a compound other than PBN. The daily dose for treating damage due to apoplexy is 10-300mg/kg and the daily dose for treating aging is 1-10mg PBN/70 kg weight in one or two divided portions and daily dose for treating ischemic damage is about 10-300mg/kg.