Covalently bound, polysaccharide-based chiral stationary phases

摘要

There are described stable, non-leaching chiral stationary phases in which a chiral polysaccharide or polysaccharide derivative is covalently bound through a spacer to the surface hydroxyl groups of a refractory inorganic oxide. The spacer molecules are omega-isocyanatoalkylene silanes. Favored refractory inorganic oxides are alumina and silica gel. Cellulose esters and cellulose phenyl carbamates are among the most favored of the chiral polysaccharides.