Calcineurin inhibitory compounds and anchoring protein
摘要
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA.
申请公布号
US5807693(A)
申请公布日期
1998.09.15
申请号
US19940344227
申请日期
1994.11.23
申请人
ICOS CORPORATION;THE STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, AND ON BEHALF OF THE OREGON HEALTH SCIENCE UNIVERSITY
发明人
SCOTT, JOHN D.;COGHLAN, VINCENT M.;HOWARD, MONIQUE L.;GALLATIN, WILLIAM M.