发明名称 |
Des-Tyr dynorphin analogues |
摘要 |
Novel peptides of the invention are dynorphin analogues and have similar activity to endogenous dynorphin, but are des-Tyr or des-Tyr-Gly with respect to endogenous dynorphin and have at least seven amino acid residues. The novel peptides have therapeutic uses, such as administration to a host tolerant to a narcotic analgesic in order to potentiate activity of the narcotic analgesic and/or to block withdrawal symptoms.
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申请公布号 |
US5807827(A) |
申请公布日期 |
1998.09.15 |
申请号 |
US19970856053 |
申请日期 |
1997.05.14 |
申请人 |
DES-TYR DYNORPHIN PARTNERSHIP |
发明人 |
LEE, NANCY M.;LOH, HORACE H.;TAKEMORI, AKIRA E. |
分类号 |
A61K38/00;C07K14/665;(IPC1-7):A61K38/00;A61K38/02;C07K5/00;C07K7/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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