发明名称 |
Antitussive drugs deliverd by partially coated ionexchange resins |
摘要 |
The present invention relates generally to a mixture of coated and non-coated sulfonic acid cation exchange resins (Amberlite IR69) cross-linked with about 8% divinyl benzene onto which dextromethorphan has been loaded. About 30% of the drug/resin complexes are coated with a mixture of ethyl cellulose or ethyl cellulose latexes with plasticizers and water dispersible polymers such as SURELEASE. The coating level is about 50% w/w drug. Coated and uncoated drug/resin complexes are loaded with drug to about 45% by weight drug/resin complex. The ratio of coated and uncoated drug/resin complexes is about 55/45. The particle sizes of the coated and uncoated drug/resin complexes is about 20 to about 300 and about 20 to about 250 microns, respectively. |
申请公布号 |
WO9827961(A3) |
申请公布日期 |
1998.09.11 |
申请号 |
WO1997US21483 |
申请日期 |
1997.11.19 |
申请人 |
WARNER LAMBERT COMPANY |
发明人 |
WEN, BETTY, P.;RAMSAY, MICHAEL, P.;SCHHEURER, HENRICH;DOKUZOVIC, ZDRAVKO;LAM, VINCENT |
分类号 |
A61K;A61K9/00;A61K9/18;A61K9/50;A61K31/485;A61K47/48 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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