METHODS AND COMPOSITIONS FOR THE TREATMENT OF INJURY TO THE CENTRAL NERVOUS SYSTEM
摘要
The invention provides methods and pharmaceutical compositions thereof for treating injury to the central nervous system (CNS). The method includes administering to the CNS of a patient suffering from such an injury a therapeutically effective amount of an inhibitor of acetylcholinesterase (AChE) production immediately following the injury. The methods use as the inhibitor a synthetic nuclease resistant antisense oligonucleotide or ribozyme that is directed against an accessible domain of the AChE mRNA brain variant. The treatment downregulates AChE production and thereby activity. The injury to the CNS may be a head injury (closed or open), brain injury, or spinal cord trauma or other trauma to the CNS.
申请公布号
WO9839486(A1)
申请公布日期
1998.09.11
申请号
WO1998US04503
申请日期
1998.03.06
申请人
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM;KOHN, KENNETH, I.;SOREQ, HERMONA;SEIDMAN, SHLOMO;SHOHAMI, ESTHER