| 摘要 |
The present invention relates to COX-2 inhibitors of formula (I) wherein, A = halogen, C1-C6alkyl, SR<1> or OR<1>; B = O, or H, H; X = Br or Cl; L = 5-, 6-, or 7-membered heteroatom containing rings and is preferably a 5-membered heteroaromatics such as thiazole, oxazole, imidazole, or oxadiazole; n = 1-6, wherein the (C) is optionally branched; R = optionally substituted aryl wherein aryl is selected from phenyl, pyridyl, naphthyl, benzothienyl, or quinoxolyl, alkyl, carboxyl, esters, amino, amide or urea; and R<1> = alkyl. The compounds are useful as research tools and could be useful as potential therapeutic agents in the inhibition of the PGHS-2 isozyme and in the treatment of inflammation in mammals including humans or other conditions associated with the production of prostaglandins.
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